APOE3 and APOE4 human astrocytes differentially modulate Alzheimer’s disease pathology and microglial responses in chimeric mice
Cell Reports
Achucarro Basque Center for Neuroscience · since 2019
Understanding human astrocytes in Alzheimer’s disease
Using human-based models to understand how astrocyte dysfunction contributes to Alzheimer’s disease and to identify new therapeutic opportunities.
What we study
Research highlights
Astrocytes are essential regulators of brain function. Our laboratory investigates how human astrocytes change during Alzheimer’s disease and how these cellular alterations influence disease progression.
Explore our researchAstrocyte dysfunction in AD
Astrocytes are key regulators of neuronal function, metabolism and brain homeostasis. We investigate how they become altered during Alzheimer’s disease and how they contribute to disease progression.
Our partners and funders
We are grateful for the support of our academic and philanthropic partners.
Latest science
Recent publications
Reprogramming aging astrocytes in Alzheimer’s disease
Trends in Neurosciences
Astrocytes as Therapeutic Targets in Neurodegenerative Disorders
Journal of Neuroscience
From the lab
Latest news
See us at GLIA 2027 in Bologna!
We are excited to announce that members of the Arranz Lab will be joining the XVIII European Meeting on Glial Cells in…
Biology in the DNA of sisters María and Paula Alfonso
Sisters and researchers María and Paula Alfonso Triguero took part in the science outreach talk “Entre llibres y provetes: Des Castell a…
Human astrocytes carrying APOE3 or APOE4 variants have distinct effects on Alzheimer’s disease
A research team from the Humanized Models of Disease Laboratory, led by Ikerbasque Professor Amaia Arranz, has published a new study in…
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Join our research
We are always looking for motivated students, postdocs and collaborators passionate about neuroscience and human disease models.
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